Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Trier (39% of total searches to Mosel Valley). The next most popular destinations are Koblenz (37%) and Cochem (18%). Searches for hotels in Bernkastel-Kues (5%) are also popular.
KAYAK users have found double rooms in Mosel Valley for as cheap as $36 (Neuwied) in the last 3 days. The average price is $171.